SR-17018 has been hailed as a "magic bullet" fix for opioid addiction, which can produce painkilling effects without tolerance or risk of overdose. Is the hype justified?

How mu opioid receptors work; what happens to them during dependence / addiction; and what causes ordinary and precipitated withdrawal. Explains receptor dynamics, antagonists / agonists (full and partial), binding affinity, downregulation, and related concepts.

Twenty years of opioid / benzo addiction in the U.S. and abroad during the apex of the failed War on Drugs. Update on my speedrun of methadone detox.

Funny and frightening stories from an American expat who weathered the COVID pandemic in Mainland China.

U.S. physicians are in dire need of specialized training in withdrawing patients from physically and psychologically addictive drugs.

An overview of mu opioid receptor dynamics that explains affinity, full agonism, partial agonism, antagonism, tolerance, and withdrawal

How to make at-home opioid detox bearable. I focus on which prescription and OTC comfort medications are must-haves and which should be...