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![The chemical structure of the opioid SR-17018, whose full name is 5,6-dichloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one.](https://static.wixstatic.com/media/6cc57b_ad00bc2577934afa9b419309044f328f~mv2.png/v1/fill/w_420,h_420,fp_0.50_0.50,lg_1,q_35,blur_30,enc_avif,quality_auto/6cc57b_ad00bc2577934afa9b419309044f328f~mv2.png)
![The chemical structure of the opioid SR-17018, whose full name is 5,6-dichloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one.](https://static.wixstatic.com/media/6cc57b_ad00bc2577934afa9b419309044f328f~mv2.png/v1/fill/w_420,h_420,fp_0.50_0.50,lg_1,q_95,enc_avif,quality_auto/6cc57b_ad00bc2577934afa9b419309044f328f~mv2.png)
SR-17018: Great Promise; A Grave Warning
SR-17018 has been hailed as a "magic bullet" fix for opioid addiction, which can produce painkilling effects without tolerance or risk of overdose. Is the hype justified?
Nov 305 min read
Video: Man in Opioid Withdrawal Explains Opioid Withdrawal
How mu opioid receptors work; what happens to them during dependence / addiction; and what causes ordinary and precipitated withdrawal. Explains receptor dynamics, antagonists / agonists (full and partial), binding affinity, downregulation, and related concepts.
May 242 min read
Opioid Receptor Dynamics 101: Full vs. Partial Agonists, Antagonists, and Precipitated Withdrawal
An overview of mu opioid receptor dynamics that explains affinity, full agonism, partial agonism, antagonism, tolerance, and withdrawal
Jun 25, 202419 min read
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